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Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Regulation of Metabolism01:19

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Updated: Jun 3, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Correlation between microRNA-21 expression and overweight/obesity.

Shashwat Sinha1, Babu Rajendran1, Shomnath Vasagam1

  • 1Vinayaka Mission's Research Foundation, Karaikal, India.

Folia Medica
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

MicroRNA-21 may play a role in obesity and overweight conditions. Further research is needed to understand this microRNA

Keywords:
BMI circulating microRNA lipid profile overweight obesity qRT-PCR

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Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Genetics

Background:

  • Obesity and overweight are major health issues linked to numerous chronic diseases.
  • While genetics and lifestyle are factors, they don't explain all cases.
  • MicroRNA-21 is implicated in hypertension, cardiac issues, and cancer, and may be a key biomarker.

Purpose of the Study:

  • To investigate the potential role of microRNA-21 in causing overweight and obesity.
  • To address conflicting data in existing literature regarding this association.

Main Methods:

  • Exploratory research based on recent scientific findings.
  • Analysis of existing literature and data on microRNA-21 and metabolic conditions.

Main Results:

  • The study explores the association between microRNA-21 and overweight/obesity.
  • Conflicting data exists, necessitating further investigation.

Conclusions:

  • Understanding the link between microRNA-21 and obesity could improve management strategies.
  • MicroRNA-21 warrants further study as a potential factor in obesity etiology.