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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
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Microbial analyses of infectious keloids on the anterior chest-a case-control study
Qian Chen1, Shen Hou1, Xiao-Yan Wu1
1Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Archives of Dermatological Research
|January 8, 2025
Summary
Infectious keloids show distinct bacterial surface differences compared to non-infectious ones. This study identifies specific bacterial genera linked to keloid infections, aiding in prediction and treatment.
Area of Science:
- Microbiology
- Dermatology
- Genetics
Background:
- Pathogens are known to cause infections in keloids via surface bacterial cultures.
- Limited research exists comparing infectious and non-infectious keloids' bacterial flora.
- Understanding microbial composition in infectious keloid foci is crucial.
Purpose of the Study:
- To compare the differential flora of purulent secretions on infectious versus non-infectious keloids.
- To determine the microbial composition within the infectious foci of keloids.
- To explore the link between microbial presence and keloid pathogenesis.
Main Methods:
- A case-control study involving 17 patients.
- Swab specimens collected from keloid surfaces (infectious and non-infectious groups) and infectious foci.
- Bacterial composition analyzed using 16S ribosomal RNA sequencing.
Main Results:
- No statistical differences in general patient condition between groups.
- Phylum Actinobacteriota, orders Propionibacteriales, Corynebacteriales, and genus Taibaiella were more prevalent on infectious keloid surfaces.
- Dominant genera in infective sites included Staphylococcus, Peptoniphilus, and Cutibacterium.
- Microbial pathways correlated with inflammation and tumor-like keloid growth.
Conclusions:
- A significant connection exists between infectious keloids and specific microorganisms.
- Findings offer insights for predicting and treating keloid infections.
- Differential bacterial analysis aids in understanding keloid pathogenesis.
