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Updated: Jul 3, 2026

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Effect of music therapy on behavioral and physiological neonatal outcomes: A systematic review and dose-response

Fatemeh Shahbazi1,2, Marzieh Fattahi-Darghlou1, Samad Moslehi3

  • 1Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Plos One
|January 8, 2025
PubMed

Insights

Music therapy significantly improves premature infant outcomes, including vital signs and sleep. Longer music exposure correlates with greater benefits, suggesting a causal link for enhanced neonatal care.

Area of Science:

  • Neonatal Medicine
  • Therapeutic Interventions
  • Evidence-Based Practice

Background:

  • Previous research confirms music therapy's efficacy for premature infants.
  • A knowledge gap exists regarding the optimal duration of music therapy for neonatal outcomes.

Purpose of the Study:

  • To determine the dose-response relationship between music therapy duration and neonatal outcomes.
  • To quantify the impact of increased music exposure on specific neonatal health indicators.

Main Methods:

  • A dose-response meta-analysis of randomized clinical trials was conducted.
  • Searches included PubMed, Scopus, Web of Science, and Cochrane Library databases.
  • A two-stage random effects model was utilized for analysis.

Main Results:

  • Each minute increase in music therapy decreased respiratory rate, pain score, and blood pressure, while improving behavioral and temperature scores.
  • Increased music exposure correlated with higher O2 saturation, heart rate, and sleep duration.
  • Analysis included 30 articles with 1855 participants.

Conclusions:

  • Music therapy positively impacts neonatal outcomes such as oxygen saturation, heart rate, respiratory rate, sleep, temperature, and blood pressure.
  • A significant dose-response relationship suggests a causal link between music therapy duration and improved neonatal health.
Abstract

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