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Updated: Jun 3, 2025

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

Published on: January 5, 2021

Developing 3D bioprinting for organs-on-chips.

Zhuhao Wu¹, Rui Liu¹, Ning Shao¹

¹Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. yjzhao@seu.edu.cn.

|January 8, 2025

Summary

This summary is machine-generated.

Organs-on-chips (OoCs) now incorporate 3D bioprinting for complex cell cultures, enhancing in vitro models. This review explores challenges and innovations in 3D bioprinted OoCs for improved biomedical research and clinical translation.

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Last Updated: Jun 3, 2025

3D Cell-Printed Hypoxic Cancer-on-a-Chip for Recapitulating Pathologic Progression of Solid Cancer

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Published on: January 5, 2021

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Published on: September 22, 2015

Area of Science:

Biomedical Engineering
Tissue Engineering
Organoid Technology

Background:

Organs-on-chips (OoCs) are advanced microphysiological systems that mimic human organ functions.
Current OoCs face limitations in structural complexity, hindering enhanced biological mimicry.
Replicating intricate organ structures on-chip remains a significant challenge in biomedical research.

Purpose of the Study:

To review the capabilities and limitations of organs-on-chips (OoCs).
To explore the integration of 3D bioprinting for creating complex OoC architectures.
To discuss the challenges and future directions for 3D bioprinted OoCs in clinical translation.

Main Methods:

Review of existing literature on organs-on-chips and 3D bioprinting techniques.
Analysis of technical and biological challenges in fabricating complex OoCs.
Discussion of recent innovations in 3D bioprinting for OoC development.

Main Results:

3D bioprinting enables the direct fabrication of complex 3D cell cultures on chips.
Innovations in bioprinting simplify OoC fabrication and increase architectural complexity.
3D bioprinted OoCs offer potential for investigating complex biological problems and advancing in vitro models.

Conclusions:

3D bioprinting significantly enhances the structural complexity and biomimetic functions of OoCs.
Overcoming fabrication and biological challenges is crucial for the development of 3D bioprinted OoCs.
Future research should focus on clinical translation and addressing remaining hurdles for widespread adoption.