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Updated: May 1, 2026
Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
Published on: September 15, 2018
Circulatory microRNAs in acute coronary syndrome: An update
Stefan Stojkovic1, Johann Wojta2,3
1Department of Cardiology, University Clinic for Internal Medicine II, Medical University of Vienna, Vienna, Austria. stefan.stojkovic@meduniwien.ac.at.
Abstract:
Micro-ribonucleic acids (miRs) are small, non-coding RNAs, which play an important role in atherosclerotic plaque formation, development, and stability. Plaque destabilization and rupture lead to acute coronary syndromes (ACS). Previous studies have implicated several different miRs in the pathogenesis of atherosclerosis. Several circulating miRs have emerged as promising diagnostic and prognostic biomarkers in ACS. Particularly cardiac- and muscle-enriched miRs including miR-1, miR-133a, miR-133b, miR-208a, and miR-499 have been associated with myocardial damage and thus proposed as potential biomarkers of ACS. In this review we summarize the role of circulating miRs as biomarkers for diagnosis and prognosis in patients with ACS, as well as recent advances and remaining challenges of miRs assessment.
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