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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
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In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
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Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

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In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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Manipulating metal-ligand binding in allosteric coordination complexes through ring strain.

Yiming Hu1, Fiona Yihan Wang1, Yi Xie1

  • 1Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, USA. chadnano@northwestern.edu.

Chemical Communications (Cambridge, England)
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Summary
This summary is machine-generated.

Ring strain in cyclic platinum complexes influences platinum-sulfur bond lability, offering a simpler way to control allosteric shape-shifting coordination complexes. This strain directs energetic preferences for specific states, simplifying effector molecule selection.

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Area of Science:

  • Coordination Chemistry
  • Organometallic Chemistry
  • Materials Science

Background:

  • The weak-link approach (WLA) enables the creation of allosteric, shape-shifting coordination complexes.
  • Chemical modification of metal-ligand interactions for tuning these complexes is synthetically challenging.

Purpose of the Study:

  • To investigate the impact of ring strain on platinum-sulfur bond lability in WLA complexes.
  • To explore ring size as a simpler alternative to chemical synthesis for controlling allosteric behavior.

Main Methods:

  • Synthesis and characterization of 4- to 8-membered cyclic platinum WLA coordination complexes.
  • Solution and solid-state studies to analyze platinum-sulfur interaction lability.
  • Investigation of the relationship between ring size and complex reactivity.

Main Results:

  • Ring strain significantly influences the lability of platinum-sulfur bonds in WLA complexes.
  • Smaller ring sizes (higher strain) correlate with altered reactivity and lability.
  • Strain can energetically favor specific allosteric states within the complexes.

Conclusions:

  • Ring strain provides a facile method to tune the allosteric properties of WLA complexes, bypassing complex chemical synthesis.
  • The degree of ring strain dictates the energetic landscape for shape-shifting.
  • This approach simplifies the selection of small molecule effectors for controlling complex interconversions.