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Related Experiment Video

Updated: Jun 23, 2026

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation
05:52

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Published on: March 8, 2018

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Virtual reality for multiple sclerosis rehabilitation.

Emma De Keersmaecker1, Stefania Guida2, Stijn Denissen3,4

  • 1Faculty of Physical Education and Physiotherapy, Rehabilitation Research Group, Vrije Universiteit Brussel, Brussels, Belgium.

The Cochrane Database of Systematic Reviews
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

Virtual reality (VR) rehabilitation may improve balance and upper limb function in multiple sclerosis (MS) patients compared to no intervention. While VR shows promise over conventional therapy for balance and quality of life, more high-quality studies are needed.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Human-Computer Interaction

Background:

  • Multiple sclerosis (MS) is a common neurological condition affecting young adults.
  • Virtual reality (VR) presents a novel rehabilitation approach offering personalized, engaging, and safe training environments.
  • VR can be adapted to individual motor and cognitive needs, potentially increasing patient motivation.

Purpose of the Study:

  • To evaluate the impact of virtual reality (VR) interventions on lower limb and gait function, balance, and postural control in individuals with MS.
  • To assess VR's effects on upper limb function, cognition, fatigue, motor function, activity limitations, participation, quality of life, and adverse events in MS patients.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted.
  • Searches included major databases (MEDLINE, Embase, CENTRAL) and trial registries up to August 2022.
  • Included studies involved VR interventions for adults (18+) with MS, assessing predefined primary and secondary outcomes.

Main Results:

  • VR interventions showed a potential improvement in balance and postural control compared to conventional therapy (moderate-certainty evidence).
  • VR may also enhance upper limb function and participation/quality of life compared to no intervention (low to very low-certainty evidence).
  • No significant differences were found for lower limb and gait function compared to conventional therapy; evidence for other outcomes was limited or uncertain.

Conclusions:

  • Virtual reality (VR) interventions show potential benefits for balance, postural control, upper limb function, and quality of life in multiple sclerosis (MS) patients.
  • VR may be superior to conventional therapy for improving balance and quality of life.
  • Further high-quality, large-scale research is necessary to confirm these findings and explore effects on other outcomes like global motor function and adverse events.