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DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in

Emília Maria Dantas Soeiro1,2,3, Maria Goretti Moreira Guimarães Penido4,5, Lucimary de Castro Sylvestre6,7

  • 1Universidade Federal de Pernambuco, Recife, PE, Brazil.

Jornal Brasileiro De Nefrologia
|January 8, 2025
PubMed

Insights

The DOMINÓ study will describe mineral and bone disorders (CKD-MBD) in Brazilian children with chronic kidney disease (CKD). This research will offer crucial data on pediatric CKD-MBD in Brazil.

Area of Science:

  • Nephrology
  • Pediatrics
  • Endocrinology

Background:

  • Pediatric chronic kidney disease (CKD) is associated with mineral and bone disorders (CKD-MBD).
  • Limited epidemiological data on pediatric CKD-MBD exists for Brazil.
  • Understanding these outcomes is vital for improving patient care.

Purpose of the Study:

  • To present the DOMINÓ study, a comprehensive epidemiological investigation.
  • To describe the characteristics of CKD-MBD in Brazilian pediatric patients.

Main Methods:

  • A retrospective and prospective, multicenter, observational cohort study.
  • Data collection includes demographics, clinical, laboratory, and imaging findings.
  • Includes pediatric patients (<18 years) with CKD stages 3-5D and kidney transplant recipients.

Main Results:

  • The study is designed to collect data from 2024 onwards.
  • Will analyze prevalent and incident cases of pediatric CKD-MBD.
  • Data will encompass a wide range of clinical and laboratory parameters.

Conclusions:

  • The DOMINÓ study will provide essential Brazilian data on pediatric CKD-MBD incidence, prevalence, and morbidity.
  • Future analyses aim to identify treatment response predictors.
  • The findings will contribute to enhanced care strategies for these patients.
Abstract

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