[Morphological changes in the nervous system in acute peroral chlorophos poisoning]

The nervous system of 14 patients who died from acute poisoning with chlorophos (Dipterex) taken orally was studied morphologically. Considerable vascular disorders, congestive plethora, perivascular edema, degeneration of collagenous and elastic fibers of vascular walls, as well as diffuse changes in brain and spinal cord cells, and in sensitive and vegetative ganglia were found. Acute swelling, severe ischemic changes were the most common forms of the cellular pathology. Pathomorphology of nervous fibers was manifested by moderate destruction of myelin sheaths of the spinal cord lateral columns, brain peduncles, and by structural changes in the axons of peripheral nerves.