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Aggressive Infection by K1/ST1265 Klebsiella pneumoniae Leading to Multiple Abscesses: Case Report and Literature
Lina Chen1,2, Canhu Qiu1, Ye Lu2
1Department of Critical Care Medicine, Jiangshan People's Hospital, Quzhou, People's Republic of China.
Abstract:
Hypervirulent Klebsiella pneumoniae (hvKp) has attracted increasing attention in recent years. Diabetes and serotype K1 or K2 are risk factors for invasive liver abscess syndrome including liver abscesses and the metastatic complications such as bacteremia, meningitis, endophthalmitis, and necrotizing fasciitis. Simultaneous infections of the liver, lungs, prostate, brain, and eyes are exceedingly rare. In this paper, a 41-year-old male patient who presented with a 4-day history of fever with polydipsia and polyuria and untreated diabetes deteriorated dramatically with sepsis, prostate abscess, lung abscess, liver abscess and intracranial infection as well as endophthalmitis. He was diagnosed with infection by K1/ST1265 hypervirulent Klebsiella pneumoniae and after treatment with antibiotics and abscess drainage, while the patient still passed away. K1/ST1265 hvKp exhibits exceptionally high virulence and invasiveness, necessitating broad awareness and vigilant monitoring.
Insights
Hypervirulent Klebsiella pneumoniae (hvKp) can cause severe, widespread infections, especially in diabetic patients. This case highlights the extreme virulence of K1/ST1265 hvKp, leading to fatal sepsis despite treatment.
Area of Science:
- Infectious Diseases
- Microbiology
- Critical Care Medicine
Background:
- Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen causing severe invasive syndromes.
- Diabetes mellitus and K1/K2 serotypes are established risk factors for hvKp liver abscesses and metastatic infections.
- Simultaneous infections across multiple organs are rare but indicate high pathogen virulence.
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