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Related Experiment Video

Updated: May 10, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
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Published on: July 10, 2014

Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.

Rui Zhao1, Xiang Meng1, Zixian Pan1

  • 1School of Medicine, Department of Inspection, Jiangsu University, Zhenjiang 212013, China.

Regenerative Biomaterials
|January 8, 2025
PubMed
Summary

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Nanohydroxyapatite (nHA), similar to bone mineral, offers excellent biocompatibility. This review covers nHA synthesis, modifications, and its diverse biomedical uses, including orthopedics, dentistry, and drug delivery.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Nanohydroxyapatite (nHA) possesses inherent biocompatibility, bioactivity, and biodegradability due to its resemblance to bone mineral.
  • Its physicochemical properties are tunable through various synthesis methods, influencing its performance in biomedical applications.

Purpose of the Study:

  • To review the synthesis techniques of nanohydroxyapatite (nHA).
  • To explore modifications of nHA, including doping with ions like magnesium and zinc.
  • To discuss the broad spectrum of nHA applications in diverse biomedical fields.

Main Methods:

  • Review of scientific literature on nHA synthesis and applications.
  • Analysis of how synthesis methods impact nHA's physicochemical properties.
Keywords:
bone regenerationcancer therapycomposite materialdentistrynanohydroxyapatite

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Last Updated: May 10, 2026

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  • Examination of nHA-based composites and their performance characteristics.

    • Main Results:

    • nHA synthesis methods significantly influence its attributes and utility.
    • Doping nHA with ions enhances bioactivity and therapeutic potential.
    • nHA composites demonstrate efficacy as bone graft substitutes, in dental applications, cancer therapy, and drug delivery systems.

    Conclusions:

    • Nanohydroxyapatite (nHA) is a versatile biomaterial with significant potential across multiple medical disciplines.
    • Further advancements in nHA synthesis and composite development promise expanded therapeutic benefits and innovative biomaterial solutions.