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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

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Association of Body Mass Index and Clinical Outcomes in Patients with Coronary Artery Disease Undergoing Percutaneous

Ting-Yu Lin^1,2,3, Hsin-Bang Leu^1,2,4,5

¹School of Medicine, National Yang Ming Chiao Tung University.

Acta Cardiologica Sinica

|January 8, 2025

Summary

The obesity paradox may apply to patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Overweight individuals (BMI 25.0-29.9 kg/m² ) showed lower risks of adverse cardiovascular events post-PCI compared to normal weight individuals.

Keywords:

Body mass index (BMI)Coronary artery disease (CAD)Major adverse cardiovascular events (MACEs)Percutaneous coronary intervention (PCI)

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Area of Science:

Cardiology
Public Health
Clinical Research

Background:

The obesity paradox describes lower mortality in overweight/obese populations.
Its relevance to patients undergoing percutaneous coronary intervention (PCI) is not well-established.

Purpose of the Study:

To investigate the association between body mass index (BMI) and cardiovascular outcomes in patients with coronary artery disease (CAD) after successful PCI.

Main Methods:

Analysis of 5,427 patients with CAD who underwent PCI (2005-2015).
Assessment of BMI's correlation with cardiovascular events, including cardiac death, myocardial infarction (MI), ischemic stroke, and heart failure (CHF) hospitalization.

Main Results:

A J-shaped relationship was observed between BMI and adverse events.
Overweight patients (BMI 25.0-29.9 kg/m²) had significantly lower risks of total CV events (HR=0.84), major adverse CV events (HR=0.76), MI (HR=0.76), and ischemic stroke (HR=0.61) compared to normal weight individuals (BMI 22.0-24.9 kg/m²).

Conclusions:

A J-shaped relationship exists between baseline BMI and future adverse events in CAD patients post-PCI.
Overweight individuals (BMI 25.0-29.9 kg/m²) experienced the lowest risk of total cardiovascular events compared to normal weight individuals.