Related Experiment Video
Updated: Jun 3, 2025
07:38
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
445
Hypothermia-associated acute pancreatitis: A multicenter prospective observational study.
Masaki Takahashi1, Shuhei Takauji1, Mineji Hayakawa1
1Division of Acute and Critical Care Medicine, Department of Anaesthesiology and Critical Care Medicine Hokkaido University Graduate School of Medicine Sapporo Japan.
Acute Medicine & Surgery
|January 8, 2025
Summary
Accidental hypothermia patients have a 3.8% risk of developing acute pancreatitis. Alcohol consumption is linked to this condition, but strong predictors remain elusive.
Area of Science:
- Emergency Medicine
- Critical Care
- Gastroenterology
Background:
- Hypothermia-associated pancreatitis is poorly understood, with limited research on its mechanisms, epidemiology, and risk factors.
- Accidental hypothermia presents a significant clinical challenge, and its association with acute pancreatitis requires further investigation.
Purpose of the Study:
- To determine the frequency and characteristics of acute pancreatitis in patients with accidental hypothermia.
- To identify potential predictive factors for the development of acute pancreatitis following accidental hypothermia.
Main Methods:
- A post hoc analysis of the multicenter prospective observational ICE-CRASH study data was performed.
- Patients (≥18 years) with core body temperatures ≤32°C admitted to emergency departments were analyzed for acute pancreatitis development within one week.
- Receiver operating characteristic (ROC) curve analysis assessed age and blood gas parameters as predictors.
Main Results:
- Out of 421 hypothermia patients, 16 (3.8%) developed acute pancreatitis within a week.
- Patients with pancreatitis showed a higher prevalence of alcohol consumption.
- Age and pH were identified as significant factors, but with limited predictive power.
Conclusions:
- The incidence of acute pancreatitis in accidental hypothermia patients (≤32°C core body temperature) is 3.8%.
- Alcohol consumption is associated with the development of acute pancreatitis in this cohort.
- No robust predictors for acute pancreatitis in accidental hypothermia were identified in this study.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
93
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
93
01:27Acute Pancreatitis I: Introduction
334
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
334
01:29Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
01:24Chronic Pancreatitis I: Introduction
71
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
71