Effects of topical epinephrine on experimental sickle cell hyphema

Experimental sickle cell hyphemas were produced by injecting human sickle cell-beta(0)-thalassemia blood into rabbit anterior chambers. Eyes treated with topical 2% epinephrine hydrochloride showed no significant difference in the duration of the hyphema or in the percentage of sickled cells in the anterior chamber compared with untreated eyes. Topical 2% epinephrine had no apparent sustained effect on intraocular pressure.