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Updated: Jun 3, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
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Interventions for quitting vaping.

Ailsa R Butler1, Nicola Lindson1, Jonathan Livingstone-Banks1

  • 1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

The Cochrane Database of Systematic Reviews
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

This living systematic review found low-certainty evidence that text message interventions and varenicline may help individuals quit nicotine vaping. More research is needed on other interventions and their impact on combustible tobacco use.

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Area of Science:

  • Public Health
  • Addiction Medicine
  • Evidence-Based Practice

Background:

  • Limited guidance exists for quitting nicotine vaping, with risks of relapse to smoking and unintended consequences.
  • Interventions for vaping cessation could include pharmacological or behavioral approaches, or a combination.

Purpose of the Study:

  • To conduct a living systematic review of interventions for nicotine vaping cessation.
  • To assess benefits and harms of interventions, including impact on combustible tobacco use.
  • To examine if intervention effects vary by participant characteristics.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) published up to April 2024.
  • Searched multiple databases (CENTRAL, MEDLINE, Embase, PsycINFO) and clinical trial registries.
  • Assessed risk of bias using Cochrane RoB 1 tool and certainty of evidence using GRADE.

Main Results:

  • Varenicline showed low-certainty evidence of increased vaping cessation (RR 2.00).
  • Text message interventions demonstrated low-certainty evidence of increased cessation in youth/young adults (RR 1.32).
  • Evidence for combination NRT and cytisine was inconclusive; no studies reported on combustible tobacco use changes.

Conclusions:

  • Text message interventions and varenicline show potential for aiding nicotine vaping cessation, particularly in younger populations.
  • Effectiveness of other interventions like NRT and cytisine requires further investigation.
  • Crucially, future research must evaluate the impact of vaping cessation interventions on combustible tobacco use.