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Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation

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Multicomponent Polymerization toward Poly(BODIPY-sulfonamide)s as Unique SO₂ Generators for Sonodynamic and Gas

Shuxin Liu¹, Juan Li², Aiguo Wang²

¹School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.

Angewandte Chemie (International Ed. in English)

|January 8, 2025

Summary

A novel multicomponent polymerization synthesized poly(BODIPY-sulfonamide)s (PBSAs) for cancer therapy. These PBSAs generate sulfur dioxide (SO2) and show significant tumor suppression via ultrasound-induced sonodynamic therapy.

Keywords:

BODIPY gas therapy multicomponent polymerization sonodynamic therapy sulfur dioxide

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Area of Science:

Polymer Chemistry
Materials Science
Nanomedicine

Background:

Developing novel therapeutic agents for cancer treatment remains a critical challenge.
Multicomponent polymerization (MCP) offers an efficient route to complex polymer structures.
Sonodynamic therapy (SDT) utilizes ultrasound to activate therapeutic agents within tumors.

Purpose of the Study:

To develop a library of poly(bipyrrole-sulfonylimide)s (PPSIs) using an MCP approach.
To create potent anticancer agents, poly(BODIPY-sulfonamide)s (PBSAs), through post-polymerization modification.
To investigate the potential of PBSAs as combined gas-releasing and sonodynamic therapeutic agents.

Main Methods:

A multicomponent polymerization (MCP) involving bipyrroles, sulfonyl azides, and diynes was employed.
Post-MCP modifications transformed bipyrrole to boron dipyrromethene (BODIPY) and sulfonylimide to sulfonamide.
Ultrasound (US) irradiation was used to induce decomposition and SO2 release from PBSAs.

Main Results:

High yields and molecular weights of PPSIs were achieved via MCP.
Synthesized poly(BODIPY-sulfonamide)s (PBSAs) demonstrated potent anticancer properties.
PBSA nanoparticles (PBSA-EG) showed remarkable in vitro and in vivo tumor suppression under US irradiation.

Conclusions:

The MCP method efficiently constructs polymers with BODIPY-sulfonamide moieties.
PBSAs function as effective sulfur dioxide (SO2) generators and sonodynamic agents.
PBSA-EG nanoparticles hold great potential for combined gas and sonodynamic cancer therapy.