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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Ferric Chloride Mediated Dearomative Spirocyclization of Biaryl Ynones: Synthesis of 3,3-Spiroindanones
Gaurav Jaiswal1, Subhas Chandra Pan1
1Department of Chemistry, Indian Institute of Technology Guwahati, Assam, 781039, India.
Abstract:
Ferric chloride mediated dearomative spirocyclization of biaryl ynones for the synthesis of new series of densely functionalized 3,3-spiroindanone derivatives has been reported. This study is the first to describe the regioselective synthesis of a five-membered ring from biaryl ynones. The scope of the reaction is broad and the spirocyclic products were obtained in moderate to good yields (up to 87 %) and with high stereoselectivities.
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