Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Molecular Weight of Step-Growth Polymers

Molecular Weight of Step-Growth Polymers

Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A disulfide-Fe<sup>3+</sup> crosslinking strategy for tough hydrogel networks with complete photo- and biochemical degradability.

Materials horizons·2026

Same author

Solvent-triggered reconfiguration of optical physical unclonable functions.

Nature communications·2026

Same author

Visualizing Millisecond Atomic Dynamics of Nanocrystals in Liquid.

Journal of the American Chemical Society·2026

Same author

Charge-engineered cellulose nanofibril binders for PFAS-free, high-loading lithium battery positive electrodes.

Nature communications·2026

Same author

De novo design of DNA origami with a generative diffusion model.

Nature communications·2026

Same author

Hydrophobic Solvation-Driven Stabilization of the Fluorenone Radical for the Anolyte of All-Organic Flow Batteries under Benign pH Conditions.

Journal of the American Chemical Society·2026

Search research articles

Related Experiment Video

Updated: Jun 3, 2025

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Elasticity of Swollen and Folded Polyacrylamide Hydrogel Using the MARTINI Coarse-Grained Model.

Seunghyok Rho¹, Heeyuen Koh², Ji Woong Yu³

¹School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

ACS Applied Materials & Interfaces

|January 8, 2025

Summary

Researchers developed a Polyacrylamide (PAAm) hydrogel model using MARTINI coarse-grained simulations. This model accurately predicts hydrogel elasticity by linking polymer conformation to bulk deformation, aiding material-specific applications.

Keywords:

MARTINI force field coarse-graining elasticity hydrogels iterative Boltzmann iteration molecular dynamics polyacrylamide swelling

More Related Videos

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Related Experiment Videos

Last Updated: Jun 3, 2025

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Area of Science:

Materials Science
Computational Chemistry
Polymer Science

Background:

Hydrogel elasticity is tunable via polymer and water content.
Understanding the molecular basis of hydrogel mechanics is crucial for material design.
Current methods struggle to simulate large-scale hydrogel behavior efficiently.

Purpose of the Study:

To develop a computationally efficient Polyacrylamide (PAAm) hydrogel model.
To establish a link between polymer conformation and hydrogel elasticity.
To enable accurate, material-specific predictions for hydrogel applications.

Main Methods:

Utilized the MARTINI coarse-grained (CG) force field for hydrogel modeling.
Employed Iterative Boltzmann Inversion (IBI) with all-atom molecular dynamics (AAMD) for model development.
Validated the CG model against experimental hydrogel properties.

Main Results:

Developed a mechanically high-fidelity CG hydrogel model of Polyacrylamide (PAAm).
Demonstrated that polymer conformation (folded to swollen states) modulates hydrogel elasticity.
Confirmed findings using the Panyukov model, linking conformation to bulk deformation.

Conclusions:

The developed MARTINI CG model provides a robust bridge between polymer structure and hydrogel mechanical properties.
This approach enables efficient exploration of large-scale hydrogel behavior.
Facilitates material-specific predictions for diverse hydrogel applications.