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Severe hypophosphataemia following denosumab administration successfully managed using a calcimimetic agent
Makiko Omori1, Yukihiro Matsukawa2, Yuhachi Ikeda1
1Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan.
BMJ Case Reports
|January 8, 2025
Summary
Denosumab treatment can cause severe hypophosphataemia and secondary hyperparathyroidism. Evocalcet effectively managed these denosumab-induced electrolyte imbalances in a young osteosarcoma patient.
Area of Science:
- Oncology
- Endocrinology
- Pharmacology
Background:
- Denosumab, an anti-RANKL antibody, reduces bone turnover by inhibiting osteoclast activity.
- Adverse events typically include infusion reactions, fever, and hypocalcemia, but hypophosphatemia is not commonly reported.
- Bone-modifying agents like denosumab can induce complex electrolyte disturbances.
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