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Delayed Gastric Emptying Correlates With Decreased Post-prandial Motility in Children: A Single-center Retrospective

Raul E Sanchez1, Elizabeth Reichard2, Adam Bobbey3

  • 1Divisions of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, OH, USA.

Journal of Neurogastroenterology and Motility
|January 8, 2025
PubMed

Insights

Delayed gastric emptying (DGE) in children is linked to abnormal antroduodenal manometry (ADM) findings, including reduced antral contractions and altered migrating motor complex patterns.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders
  • Diagnostic Endoscopy

Background:

  • Pediatric gastroparesis diagnosis often involves antroduodenal manometry (ADM) and gastric emptying scintigraphy (GES).
  • Correlation between delayed gastric emptying (DGE) and ADM findings in children remains unclear.
  • This study investigates ADM parameter differences in pediatric patients with normal versus abnormal GES.

Purpose of the Study:

  • To determine if antroduodenal manometry (ADM) parameters differ between pediatric patients with delayed gastric emptying (DGE) and normal gastric emptying (NGE).
  • To identify specific manometric abnormalities associated with DGE in children.

Main Methods:

  • Retrospective review of pediatric patients undergoing ADM and GES (2011-2020).
  • Comparison of manometry parameters (motility index, contraction number, phase III migrating motor complex [MMC]) between DGE (n=32) and NGE (n=32) groups.
  • Age, sex, BMI, and weight-matched patient cohorts were analyzed.

Main Results:

  • Children with DGE exhibited lower post-prandial antral motility index and contraction numbers compared to NGE.
  • Lower gastric emptying at 4 hours was observed in patients with retrograde phase III MMC or absent antral component in fasting phase III MMC.
  • Post-prandial antral hypomotility was significantly more frequent in the DGE group.

Conclusions:

  • Antroduodenal manometry (ADM) findings are distinct between pediatric patients with delayed gastric emptying (DGE) and normal gastric emptying (NGE).
  • Children with DGE are more prone to abnormal fasting phase III patterns and reduced post-prandial antral activity on ADM.
Abstract

Keywords:
Gastric emptying scintigraphyGastrointestinal motilityGastroparesisManometryPediatrics

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