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Preoperative frailty in oesophageal cancer: postoperative outcomes and overall survival - meta-analysis and systematic review

  • 0Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Bmj Supportive & Palliative Care +

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January 8, 2025

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January 8, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative frailty is common in esophageal cancer patients, affecting nearly 30%. It significantly increases risks of death, complications, and readmission after surgery, highlighting the need for early detection and intervention.

Area Of Science

  • Oncology
  • Geriatrics
  • Surgical Outcomes Research

Background

  • Esophageal cancer is a significant global health concern.
  • Patient frailty is increasingly recognized as a critical factor influencing surgical outcomes.
  • Understanding preoperative frailty prevalence in esophageal cancer is essential for risk stratification.

Purpose Of The Study

  • To determine the prevalence of preoperative frailty in patients undergoing surgery for esophageal cancer.
  • To evaluate the impact of preoperative frailty on postoperative outcomes, including mortality and complications.
  • To assess the association between preoperative frailty and overall survival in this patient cohort.

Main Methods

  • A systematic literature search was performed across multiple databases (CNKI, Wanfang, VIP, CBM, PubMed, Embase, Cochrane Library, Web of Science, CINAHL) up to April 20, 2024.
  • Included studies focused on preoperative frailty in esophageal cancer patients.
  • Meta-analysis was used to synthesize data on frailty prevalence, postoperative outcomes, and overall survival.

Main Results

  • Thirteen studies involving 53,485 patients were analyzed.
  • The pooled prevalence of preoperative frailty was 29.6% (95% CI 24.5% to 34.8%).
  • Preoperative frailty was associated with increased postoperative mortality (HR 1.80), complications (HR 1.32), and 30-day readmission (HR 1.24), but not overall survival (HR 1.28).

Conclusions

  • A high prevalence of preoperative frailty exists among patients with esophageal cancer.
  • Preoperative frailty is a significant predictor of adverse postoperative outcomes.
  • Early identification and targeted interventions for frailty are crucial to mitigate postoperative risks in esophageal cancer patients.

Keywords:

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