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Updated: Jun 3, 2025

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
[Research advances on the genetic pathogenesis and gene therapy for pancreatitis]
Yizhou Zheng1, Yuanchen Wang, Wenbin Zou
1Research Institute for Pancreatic Diseases of Shanghai, Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. dr.wenbinzou@hotmail.com.
Abstract:
Pancreatitis is an inflammatory disease influenced by both environmental and genetic factors. It has a high prevalence and mortality rate worldwide, with no radical cure. Breakthroughs have been recently made in genetic research of pancreatitis. Susceptibility genes and pathways have been continuously discovered, which highlighted the roles of genetic factors in hypertriglyceridemic and chronic pancreatitis. Gene therapy may offer radical cure for pancreatitis, though it has remained at the research phase. This article has reviewed the genetic pathogenesis of pancreatitis and current status of gene therapy research, with an aim to provide a reference for attaining definitive cure for the disease.
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