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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Updated: Jun 3, 2025

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Morbid Obesity and Liver Transplant.

Gerardo Moro1, Arkaitz Perfecto2, Jaime Encinas1

  • 1BioBizkaia Research Health Institute. Barakaldo, Bizkaia, Spain.

Transplantation Proceedings
|January 8, 2025
PubMed
Summary

Morbid obesity (MO) does not contraindicate liver transplantation (LT). Patients with MO undergoing LT showed satisfactory outcomes, with 97% patient and graft survival at 5 years, suggesting MO should not be a contraindication.

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Area of Science:

  • Hepatology
  • Transplantation Surgery
  • Bariatric Medicine

Background:

  • Rising prevalence of morbid obesity (MO) impacts various patient populations.
  • MO is increasingly observed in patients with liver disease eligible for liver transplantation (LT).

Purpose of the Study:

  • To evaluate the impact of morbid obesity on morbidity, mortality, and survival after liver transplantation.
  • To determine if MO should be considered a contraindication for LT.

Main Methods:

  • Retrospective analysis of a single-center cohort of patients with MO undergoing LT.
  • Data collected on body mass index (BMI), indications for LT, postoperative complications, and survival rates.

Main Results:

  • Fifteen patients with BMI ≥ 40 kg/m² underwent LT between 2004-2023.
  • Common indications included liver cirrhosis (93%); 5 patients experienced major complications.
  • Five-year patient and graft survival rates were high at 97%.

Conclusions:

  • Liver transplantation in patients with morbid obesity yielded satisfactory postoperative outcomes and survival.
  • Morbid obesity should not be considered an absolute contraindication for liver transplantation.