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Updated: Jun 3, 2025

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
Published on: November 28, 2015
Mpox-Induced Metabolic Alterations
Milad Zandi1, Fatemeh Sadat Mousavi2, Seyyed Mohammed Reza Hashemnia3
1Iranian Society for Virology, Deputy for Education, Ministry of Health and Medical Education, Tehran, Iran.
Abstract:
The resurgence of mpox as a global health threat highlights the need to understand its interaction with host cell metabolism. Unlike other well-studied viruses, research on mpox is limited, particularly regarding its impact on cellular processes. In this article, we explore how mpox might manipulate metabolic pathways-such as glycolysis, lipid synthesis and mitochondrial dynamics-to enhance its replication and evade immune responses. By drawing parallels with related poxviruses, we underscore the potential for targeting these metabolic shifts as novel therapeutic strategies. Understanding these interactions is crucial for developing effective treatments against mpox.
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