Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
Cancer Vaccines01:30

Cancer Vaccines

337
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
337
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

841
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
841
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.8K
Overview
66.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

450
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
450
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IL-33 scripts cancer immunity.

Trends in immunology·2026
Same author

Lenvatinib Combined with PD-1 Blockade Therapy Benefits Gastric Cancers through Immunosuppressive Macrophage Modulation.

Cancer immunology research·2026
Same author

On-demand GLUT3 expression augments CAR T cell metabolic fitness and antitumor efficacy in preclinical models of glioblastoma.

Science translational medicine·2026
Same author

Ponatinib inhibits LCK and PI3K signaling and promotes CD8<sup>+</sup> T stem cell memory cell development.

Nature communications·2026
Same author

Concurrent Pituitary and Thyroid Immune-Related Adverse Events after Immune Checkpoint Inhibitors Associated with HLA-DR15-Related Haplotypes.

Cancer immunology research·2026
Same author

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade.

Nature medicine·2026

Related Experiment Video

Updated: Jun 3, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

836

Reinventing type 2 immunity in cancer.

Marek Wagner1, Hiroyoshi Nishikawa2,3, Shigeo Koyasu4,5

  • 1Innate Immunity Research Group, Life Sciences and Biotechnology Center, Łukasiewicz Research Network-PORT Polish Center for Technology Development, Wrocław, Poland. marek.wagner@port.lukasiewicz.gov.pl.

Nature
|January 8, 2025
PubMed
Summary
This summary is machine-generated.

Type 2 immunity, beyond fighting parasites, also regulates tissue repair and suppresses harmful type 1 responses. Contrary to past beliefs, it may protect against cancer, offering new avenues for immunotherapy.

More Related Videos

Author Spotlight: Efficient Detection of Immune Cell-Infiltration in Cancer Tissues Using Fluorescent Immunohistochemistry
04:21

Author Spotlight: Efficient Detection of Immune Cell-Infiltration in Cancer Tissues Using Fluorescent Immunohistochemistry

Published on: January 26, 2024

658
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

280

Related Experiment Videos

Last Updated: Jun 3, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

836
Author Spotlight: Efficient Detection of Immune Cell-Infiltration in Cancer Tissues Using Fluorescent Immunohistochemistry
04:21

Author Spotlight: Efficient Detection of Immune Cell-Infiltration in Cancer Tissues Using Fluorescent Immunohistochemistry

Published on: January 26, 2024

658
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

280

Area of Science:

  • Immunology
  • Cancer Biology
  • Inflammation

Background:

  • Type 2 immunity traditionally linked to parasite defense.
  • Emerging roles in tissue repair and immune regulation.
  • Previous perception of type 2 immunity as tumor-promoting.

Purpose of the Study:

  • To review recent discoveries on type 2 immunity's functions.
  • To explore type 2 immunity's dual role in cancer.
  • To highlight its potential in cancer immunotherapy.

Main Methods:

  • Literature review of recent immunological and cancer research.
  • Analysis of studies investigating type 2 immunity in various physiological and pathological contexts.
  • Synthesis of evidence regarding type 2 immunity's impact on tumorigenesis.

Main Results:

  • Type 2 immunity has diverse roles beyond anti-parasitic defense.
  • Evidence suggests type 2 immunity can suppress tumor growth.
  • Type 2 immunity's role in cancer is more complex than previously thought.

Conclusions:

  • Type 2 immunity's multifaceted functions are increasingly recognized.
  • Type 2 immunity may represent a novel target for cancer therapies.
  • Further research into type 2 immunity could revolutionize cancer treatment.