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Related Experiment Video

Updated: May 14, 2026

An “All-laser” Endothelial Transplant
09:59

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Safety and Efficacy of Combination Therapy with Anti-Vascular Endothelial Growth Factor and Laser for Retinopathy of

Anas Alamoudi1, Ahmed N Alnabihi2,3, Ali Saleh Alsudais2,3

  • 1Department of Ophthalmology, Jeddah Eye Hospital, Jeddah, Saudi Arabia.

Clinical Ophthalmology (Auckland, N.Z.)
|January 9, 2025
PubMed
Summary

Combined laser and anti-VEGF therapy for retinopathy of prematurity (ROP) shows favorable outcomes, though not statistically significant. Safety profiles are comparable to other treatments, but more research is needed due to limited studies.

Keywords:
angiogenesis inhibitorsneonatal retinal diseasepremature infant eye healthretinal photocoagulation

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Area of Science:

  • Ophthalmology
  • Neonatology
  • Medical Research

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
  • Current treatments for ROP include laser photocoagulation and anti-vascular endothelial growth factor (anti-VEGF) therapy.
  • The combination of laser and anti-VEGF therapy is being explored for improved efficacy and safety.

Purpose of the Study:

  • To systematically review and meta-analyze the safety and efficacy of combined laser and anti-VEGF therapy for ROP.
  • To evaluate both structural and functional outcomes of this combination therapy.
  • To compare the combination therapy with other interventions used for ROP.

Main Methods:

  • A comprehensive search of multiple databases was performed to identify relevant randomized controlled trials (RCTs).
  • The meta-analysis followed PRISMA guidelines, extracting data and analyzing it using risk ratios and 95% confidence intervals (CIs).
  • The Cochrane Risk of Bias tool was utilized to assess the risk of bias in the included studies.

Main Results:

  • Three RCTs with a total of 162 premature infants were included.
  • Pooled analysis showed no statistically significant difference in favorable structural outcomes between combination therapy and control interventions (P=0.25).
  • The incidence of adverse events was comparable between the combination therapy group and other intervention groups.

Conclusions:

  • Combined anti-VEGF and laser therapy for ROP is associated with favorable outcomes, although the current evidence is not statistically significant.
  • The safety profile of this combination therapy appears similar to other ROP interventions.
  • Further research is warranted due to the limited number of studies included in this meta-analysis.