Related Experiment Video

Updated: Jul 7, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

24.1K

Features of Physical and Psychomotor Development in Children with Brain Ischemia

Guldana O Shoibekova1, Mira N Turbekova2, Farida A Iskakova3

  • 1Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Kazakhstan.

Medical Journal of the Islamic Republic of Iran
|January 9, 2025
PubMed

Insights

Brain ischemia in infants can lead to physical disharmony in 19.5% and psychomotor dysfunction in 35%. These developmental issues are linked to maternal factors and infant characteristics, impacting long-term child health.

Area of Science:

  • Pediatrics
  • Neurology
  • Developmental Biology

Background:

  • Infant brain ischemia is a significant cause of morbidity and mortality.
  • Numerous factors influence the severity and consequences of brain ischemia in children.
  • Understanding developmental outcomes is crucial for managing affected infants.

Purpose of the Study:

  • To characterize the physical and psychomotor development of children following brain ischemia.
  • To identify associations between brain ischemia and developmental outcomes.
  • To explore prognostic factors influencing development post-ischemia.

Main Methods:

  • Studied 246 full-term infants with mild to moderate brain ischemia (ICD-10 codes: 91.1-91.4).
  • Assessed physical development using centile tables and psychomotor development via the Griffiths scale.
  • Employed statistical analyses including Pearson chi-square, Kaplan-Meier method, and logistic regression.

Main Results:

  • Prevalence of physical disharmony was 19.5%; psychomotor dysfunction was 35.0%.
  • Significant association found between physical and psychomotor development (P ≤ 0.001).
  • Factors influencing outcomes included female sex, advanced maternal age, lower birth weight, and complicated childbirth.

Conclusions:

  • Brain ischemia is associated with significant rates of physical disharmony and psychomotor dysfunction.
  • Developmental issues are interrelated with maternal and infant prognostic characteristics.
  • Combined physical and psychomotor dysfunction occurred in 11.8% of cases.
Abstract

Keywords:
Brain IschemiaChild DevelopmentDysfunctionMotor SkillsSensory Motor Performances

More Related Videos

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury08:32

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury

Published on: November 24, 2017

12.2K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

737

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...