Related Experiment Video For DNA methylation
Updated: May 13, 2026
Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
Published on: February 24, 2015
Research Progress of DNA Methylation Markers for Endometrial Carcinoma Diagnosis
Haoning Zheng1,2, Cuisong Yu3, Lu Yang1
1Clinical Pathology Department, Shandong Second Medical University, Shandong Province, Weifang, Shandong 261042, P.R. China.
Abstract:
Endometrial carcinoma (EC) is the most common malignancies of the female reproductive system in developed countries and areas. Ultrasound-guided and hysteroscopic samplings are commonly used to diagnose EC. However, clinicians question their diagnostic efficacy and the associated patient discomfort. DNA methylation is the widely studied epigenetic alteration in human tumors, and tumor screening and diagnosis. This review summarized common methods for collecting clinical samples for methylation testing. Furthermore, we analyzed the diagnostic evaluation indices of different methylation marker assays in clinical diagnosis and discussed the challenges of methylation testing in the future application of EC diagnosis.
