Related Experiment Video
Updated: May 5, 2026

08:43
Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
Published on: April 3, 2018
9.8K
Vitamin C-Based Gingival Depigmentation Versus Surgical Depigmentation: A Randomized Clinical Trial
Aehad Ul Haque1, Nand Lal1, Shalini Kaushal1
1Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.
Thescientificworldjournal
|January 9, 2025
Summary
This study compared vitamin C injections and surgical methods for gingival depigmentation. Both were effective, but patients preferred vitamin C for higher satisfaction with the cosmetic outcome.
Area of Science:
- Periodontology
- Cosmetic Dentistry
Background:
- Gingival hyperpigmentation, often related to ethnicity, affects aesthetics.
- Gingival depigmentation aims to improve the appearance of pigmented gums.
Purpose of the Study:
- To compare the effectiveness and patient acceptability of locally injected vitamin C versus surgical depigmentation for treating gingival hyperpigmentation.
Main Methods:
- A randomized controlled trial involving 42 patients with ethnicity-related gingival hyperpigmentation.
- Group I received locally injected vitamin C; Group II underwent surgical depigmentation.
- Outcomes assessed using Gingival Pigmentation Index (GPI), Skin Hyperpigmentation Index (SHI), and Visual Analog Scale (VAS) for patient satisfaction.
Main Results:
- Both vitamin C injections and surgical depigmentation effectively treated gingival hyperpigmentation.
- Patients treated with vitamin C reported significantly higher satisfaction scores (VAS).
Conclusions:
- Locally injected vitamin C and surgical depigmentation demonstrate comparable effectiveness in treating gingival hyperpigmentation.
- Vitamin C injection offers superior patient-reported satisfaction compared to surgical methods.

