Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials

Area of Science:

• Biomaterials Science
• Biomedical Engineering
• Molecular Biology

Background:

• Biopolymers (collagens, elastin, silk, fibrin, keratin, resilin) offer biocompatibility and biodegradability for biomedical uses.
• Biomimetic peptides can be integrated into biopolymer platforms to enhance functionality.
• Controlling bioactive molecule release is key for advanced biomedical applications.

Purpose of the Study:

• To review the design and integration of biomimetic peptides into biopolymer platforms.
• To explore how these engineered peptides enhance drug delivery, tissue engineering, and regenerative medicine.
• To highlight achievements and future directions in biomimetic peptide-biopolymer systems.

Main Methods:

• Review of literature on engineered peptides (e.g., elastin-like polypeptides, silk fibroin repeats, spider silk proteins, fibrin-binding peptides, collagen-mimetic peptides, resilin-like peptides).
• Analysis of peptide integration strategies for controlled bioactive molecule release.
• Evaluation of biomimetic peptide influence on biopolymer material properties.

Main Results:

• Engineered peptides, such as elastin-like polypeptides and silk fibroin repeats, mimic natural domains to modulate material properties and drug release.
• Recombinant spider silk, fibrin-binding, collagen-mimetic, and keratin-derived peptides enable precise interactions and controlled release systems.
• Resilin-like peptides demonstrate potential for creating highly elastic and resilient biomaterials.

Conclusions:

• Biomimetic peptides offer a powerful strategy to functionalize biopolymers for biomedical applications.
• The precise engineering of peptides allows for tailored control over material properties and bioactive molecule release.
• This approach holds significant potential to advance drug delivery, tissue engineering, and regenerative medicine.