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Updated: Jun 3, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal
Ángel Fernández-Sanromán1,2, Annika Fendler3, Benjy J Y Tan1
1Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.
Significance:
Using joint genomic-transcriptomic analysis of 243 samples, we reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor T-cell receptor coevolution, potential cGAS-STING repression, and increased cell proliferation. These patterns can aid clinical management and guide novel treatment approaches.
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