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Hippocampal unit activity and delayed response in the monkey.

T Watanabe, H Niki

    Brain Research
    |January 28, 1985
    PubMed
    Summary
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    The hippocampus is involved in the delayed response (DR) task, as shown by changes in neuronal activity in Japanese monkeys. Many hippocampal neurons, particularly delay units, showed significant firing rate changes during the task.

    Area of Science:

    • Neuroscience
    • Cognitive Neuroscience

    Background:

    • The delayed response (DR) task is crucial for assessing cognitive functions like working memory.
    • The hippocampus is implicated in memory and spatial navigation, but its precise role in DR tasks requires further elucidation.

    Purpose of the Study:

    • To investigate hippocampal neuronal activity during a delayed response (DR) task in Japanese monkeys.
    • To classify neuronal responses based on task events and identify specific neuronal populations involved.

    Main Methods:

    • Single unit activity was recorded from the hippocampus of four Japanese monkeys (Macaca fuscata).
    • Monkeys performed a delayed response (DR) task.
    • Neuronal discharge rates were analyzed in relation to task events (cue, choice, response, reward, error).

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    Main Results:

    • 272 hippocampal units exhibited significant changes in discharge rate during the DR task.
    • Units were categorized into cue-related, choice-related, response-related, reward-error, and delay units.
    • Delay units (43.4% of related units) showed preferential firing during the delay period, with some exhibiting spatially dependent activity.

    Conclusions:

    • Hippocampal neuronal activity dynamically changes during the delayed response (DR) task.
    • Specific neuronal populations within the hippocampus are involved in different phases of the DR task, including cue, delay, and response periods.
    • These findings provide experimental evidence for the hippocampus's involvement in the cognitive processes underlying the DR task.