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Riluzole is associated with reduced risk of heart failure
Kibum Kim1, Sodam Kim1, Margaret Katana1
1Department of Pharmacy Systems and Outcomes and Policy, University of Illinois Chicago, Chicago, Illinois, USA.
European Journal of Neurology
|January 9, 2025
Summary
Riluzole, a medication for amyotrophic lateral sclerosis (ALS), may help prevent heart failure (HF). Studies show riluzole is associated with a lower incidence of HF, suggesting its potential as an early management strategy.
Area of Science:
- Cardiology
- Pharmacology
- Neurology
Background:
- Late sodium current inhibition is a target for heart failure (HF) management by affecting intracellular sodium and calcium handling.
- Riluzole, used for amyotrophic lateral sclerosis (ALS), blocks sodium channels and enhances calcium-activated potassium channels, potentially improving cardiac function by suppressing calcium leak.
Purpose of the Study:
- To investigate the potential of riluzole in lowering the incidence of heart failure (HF).
Main Methods:
- A comparative analysis of HF incidence was conducted using insurance and Medicare claims databases.
- Patients with riluzole prescriptions were compared to a control group without riluzole, excluding those with prior HF.
- Propensity score matching was used to compare HF onset between treatment and control cohorts.
Main Results:
- The study included 4060 matched pairs of riluzole and control patients.
- Riluzole use was associated with a significantly lower 24-month cumulative incidence of HF onset (4.96% vs. 7.27%, HR 0.55).
- This effect was primarily driven by a reduced rate of heart failure with reduced ejection fraction (HFrEF).
Conclusions:
- Riluzole is linked to a reduced incidence of heart failure (HF) onset.
- These findings suggest riluzole may serve as a potential preventive strategy in the early stages of HF management.
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