Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.1K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.7K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.7K
Stem Cell Niche01:26

Stem Cell Niche

5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Production of Formed Elements01:34

Production of Formed Elements

1.3K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical, biochemical and molecular spectrum of acute neuronopathic type 2 Gaucher disease from India.

BMC pediatrics·2026
Same author

Development of national biobank for lysosomal storage disorders in India- a step towards advancing research and precision medicine.

Orphanet journal of rare diseases·2026
Same author

BrainProt v3.0: An Integrative and Simplified Omics-Based Knowledge-Base About the Human Brain and Its Associated Diseases.

Journal of proteome research·2025
Same author

Prenatal diagnosis of rare genetic disorders: fourteen years' experience of a tertiary genetic centre from India.

Orphanet journal of rare diseases·2025
Same author

Molecular dynamics simulations of perforin mutations associated with familial hemophagocytic lymphohistiocytosis type 2 among Indian patients.

International journal of biological macromolecules·2025
Same author

Burden of rare genetic disorders in India: twenty-two years' experience of a tertiary centre.

Orphanet journal of rare diseases·2024

Related Experiment Video

Updated: Jun 3, 2025

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

8.5K

'Nomadic' Hematopoietic Stem Cells Navigate the Embryonic Landscape.

Anand Badhri Narayan1, Senthil Kumar Hariom1, Ayan Prasad Mukherjee1

  • 1Department of Integrative Biology, Gene Therapy Laboratory, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, TN, 632 014, India.

Stem Cell Reviews and Reports
|January 9, 2025
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) rely on their niche for function, but aging niches impair this. Zebrafish models offer insights into HSC regulation and potential therapeutic strategies.

Keywords:
And EpigeneticsHematopoiesisHematopoietic stem CellsHumanStem cell NicheZebrafish

More Related Videos

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

10.9K
Isolation of Murine Embryonic Hemogenic Endothelial Cells
08:56

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

11.4K

Related Experiment Videos

Last Updated: Jun 3, 2025

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

8.5K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

10.9K
Isolation of Murine Embryonic Hemogenic Endothelial Cells
08:56

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

11.4K

Area of Science:

  • Hematology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for blood cell regeneration, residing in a specialized microenvironment (niche).
  • Niche-derived signals regulate HSC survival, activation, and quiescence, with aging niches leading to functional decline.
  • Observing in vivo HSC regulation has been challenging due to limited methods.

Purpose of the Study:

  • To review the role of the stem cell niche in regulating hematopoiesis.
  • To highlight the utility of Danio rerio (zebrafish) as a model for studying HSCs in vivo.
  • To discuss epigenetic regulators and physiological processes sustaining HSC populations.

Main Methods:

  • Review of existing literature on hematopoietic stem cells and their niche.
  • Focus on studies utilizing the zebrafish model for hematopoiesis research.
  • Analysis of epigenetic and physiological factors influencing HSC function.

Main Results:

  • Zebrafish provide a powerful platform for dissecting cellular interactions and regulatory factors of HSCs.
  • Epigenetic regulators and physiological processes are critical for maintaining HSC populations.
  • Niche understanding is key to advancing cell therapy, organoid cultures, and aging research.

Conclusions:

  • The zebrafish model significantly advances our understanding of vertebrate hematopoiesis.
  • Targeting the stem cell niche holds promise for therapeutic applications, including bone marrow transplantation and cancer treatment.
  • Further research into niche components can improve HSC differentiation and transplantation outcomes.