Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

501
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
501
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

860
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
860
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

233
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
233
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

93
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
93

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interstitial granulomatous dermatitis presenting with the rope sign in a patient with systemic lupus erythematosus.

JAAD case reports·2026
Same author

Neutrophilic Eccrine Hidradenitis in a Patient With Intranasal Cocaine Use.

The Australasian journal of dermatology·2026
Same author

Rural, Regional, Remote Residence, Anxiolytic Use, Multiple Site Surgery, Smoking Status Associated With Patient-Initiated Communication After Mohs Micrographic Surgery.

The Australasian journal of dermatology·2026
Same author

Familial prevalence of psoriasis in patients with multiple sclerosis - results from an Australian survey.

Frontiers in neurology·2025
Same author

Severe hypertriglyceridaemia with length-related small fibre sensory neuropathy as a complication of previous gestational diabetes mellitus.

Endocrinology, diabetes & metabolism case reports·2025
Same author

Treatment of Hallux Rigidus: Comparison of Hemiarthroplasty with Cartiva Implant, Allograft Interpositional Arthroplasty, and Arthrodesis.

Foot & ankle orthopaedics·2025

Related Experiment Video

Updated: Jun 3, 2025

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

1.6K

Severe palmoplantar keratoderma: a cutaneous complication from sub-optimally controlled type 2 diabetes.

Fatima Iqbal1,2, Kevin Phan3,4, Wah N Cheung1,5

  • 1Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, New South Wales, Australia.

Endocrinology, Diabetes & Metabolism Case Reports
|January 9, 2025
PubMed
Summary

This case highlights a rare skin complication, palmoplantar keratoderma (PPK), in a patient with poorly controlled type 2 diabetes and a severe infection. Effective management requires addressing both the infection and diabetes, alongside specialized dermatological care for PPK.

Keywords:
palmoplantar keratodermatype 2 diabetes

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

196
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.0K

Related Experiment Videos

Last Updated: Jun 3, 2025

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

1.6K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

196
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.0K

Area of Science:

  • Endocrinology
  • Dermatology
  • Infectious Diseases

Background:

  • Palmoplantar keratoderma (PPK) is characterized by excessive skin thickening on the palms and soles, which can be hereditary or acquired.
  • Sub-optimally controlled diabetes mellitus is a risk factor for various complications, including rare dermatologic manifestations.
  • This case involves a patient with type 2 diabetes presenting with diabetic ketoacidosis (DKA) and a severe necrotizing soft tissue infection.

Purpose of the Study:

  • To report a case of palmoplantar keratoderma (PPK) in a patient with poorly controlled diabetes and a severe infection.
  • To emphasize the importance of thorough dermatological assessment in diabetic patients.
  • To highlight the need for a multidisciplinary approach in managing complex diabetes-related complications.

Main Methods:

  • A 53-year-old female patient with a history of poorly controlled diabetes presented with DKA and a back infection.
  • The patient exhibited marked plantar keratoderma and onychogryphosis, diagnosed as PPK.
  • Treatment involved surgical debridement, antibiotics, DKA management, and topical urea cream for PPK.

Main Results:

  • The patient was diagnosed with DKA and a methicillin-sensitive Staphylococcus aureus necrotizing soft tissue infection.
  • Marked plantar keratoderma and onychogryphosis were observed, attributed to sub-optimally managed diabetes.
  • Treatment with 40% urea cream resulted in gradual resolution of hyperkeratotic skin within weeks.

Conclusions:

  • Sub-optimal diabetes control can lead to rare dermatologic complications like PPK.
  • Prompt identification and management of infections are crucial in diabetic patients.
  • A multidisciplinary approach involving dermatology, endocrinology, and allied health services is essential for comprehensive diabetes care and complication management.