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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

David Trombley McSwiggen1, Helen Liu1, Ruensern Tan1

  • 1Eikon Therapeutics Inc, Hayward, United States.

Elife
|January 9, 2025
PubMed
Summary

High-throughput single-molecule tracking (htSMT) enables large-scale analysis of protein dynamics in cells. This method accelerates drug discovery by rapidly identifying compounds that modulate protein function, like the estrogen receptor (ER).

Keywords:
cell biologydrug discoveryestrogen receptorhigh-throughput imaginghumanlive-cell imagingphysics of living systemsprotein motionsingle-molecule imaging

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