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Changes in serum periostin levels in uncontrolled asthma in children (DADO phase 2 study)

Alicia Habernau Mena1,2, Maria Angela Gonzalo Garijo3, Victoria Del Pozo Abejón4

  • 1Department of Allergology, Hospital de Mérida, Badajoz, Spain.

Allergologia Et Immunopathologia
|January 9, 2025
PubMed

Insights

Periostin levels significantly decreased in children with uncontrolled asthma after 12 months of optimized management, indicating its potential as a biomarker for asthma control. This finding highlights improved asthma management in pediatric patients.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Biomarker Discovery

Background:

  • Asthma is a prevalent chronic inflammatory airway disease in children, yet lacks specific biological markers.
  • Identifying reliable biomarkers is crucial for monitoring disease activity and treatment efficacy in pediatric asthma.

Purpose of the Study:

  • To investigate changes in serum periostin levels in children with uncontrolled asthma following 12 months of optimized management.
  • To assess the correlation between periostin levels and improvements in asthma symptoms, lung function, and quality of life.

Main Methods:

  • Prospective observational study involving children aged 5-14 with uncontrolled asthma.
  • Assessment of lung function, asthma control test (ACT), Paediatric Asthma Quality of Life Questionnaire (PAQLQ), blood eosinophils, IgE, and serum periostin at baseline and after 12 months.
  • Comparison of periostin levels with a control group.

Main Results:

  • Serum periostin levels in children with uncontrolled asthma decreased significantly from 901.48 ng/ml to 67.93 ng/ml after 12 months (p<0.001).
  • Periostin levels in the control group were 56.12 ng/ml.
  • Improvements observed in asthma symptoms, lung function (FEV1), asthma control (ACT), and quality of life (PAQLQ) post-treatment.

Conclusions:

  • Serum periostin levels decrease significantly with effective asthma management in children.
  • Periostin shows potential as a biomarker for monitoring asthma control and treatment response in pediatric populations.
  • The study supports the utility of periostin in assessing the effectiveness of asthma management strategies.
Abstract

Keywords:
asthmabiomarkerschildreneosinophilsperiostin

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