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Updated: Jun 3, 2025
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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
Published on: December 8, 2023
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Kidney Disease and Hematopoietic Stem Cell Transplantation
Amanda DeMauro Renaghan1, José Maximino Costa2, Alexandra Esteves3
1Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia.
Kidney360
|January 9, 2025
Summary
Hematopoietic stem cell transplantation (HSCT) can cause acute kidney injury (AKI) and chronic kidney disease (CKD). Understanding risk factors and causes is crucial for preventing and treating these common post-transplant complications.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Hematopoietic stem cell transplantation (HSCT) offers curative potential for various hematologic and oncologic conditions.
- Acute kidney injury (AKI) and chronic kidney disease (CKD) are frequent and serious complications following HSCT.
Purpose of the Study:
- To provide a comprehensive review of kidney diseases after HSCT.
- To highlight recent advancements in the diagnosis, prevention, and treatment of post-HSCT AKI and CKD.
Main Methods:
- Literature review focusing on epidemiology, risk factors, etiologies, pathophysiology, diagnosis, prevention, and treatment.
- Emphasis on recent scientific advances in the field of HSCT-related nephrotoxicity.
Main Results:
- Post-HSCT AKI and CKD arise from transplant effects, conditioning regimens, and nephrotoxic medications.
- These kidney complications significantly increase patient morbidity and mortality.
Conclusions:
- Kidney injury is a major concern in HSCT recipients.
- Ongoing research and clinical attention are vital for improving outcomes in patients undergoing HSCT.
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