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Omadacycline for the treatment of skin and soft tissue infections
Antonio Vena1,2, Nadia Castaldo3, Daniele Roberto Giacobbe1,2
1Department of Health Sciences (DISSAL), University of Genoa.
Purpose Of Review:
To evaluate the current evidence on the use of omadacycline for the treatment of skin and soft tissue infections (SSTIs).
Recent Findings:
This narrative review examines the available data on the pharmacology, clinical efficacy, safety profile, and comparative effectiveness of omadacycline in treating SSTIs, with a focus on its potential role in everyday clinical practice.
Summary:
Omadacycline is a viable option for outpatient therapy and early discharge in patients with SSTIs, particularly in frail populations and those undergoing chronic polypharmacotherapy. Emerging real-world evidence highlights its potential utility beyond approved indications, particularly for infections caused by multidrug-resistant microorganisms where treatment options are limited. However, further studies are needed to confirm its role in contexts beyond its current approvals.
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