Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

47.9K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
47.9K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

3.2K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
3.2K
Introduction to the Skeletal System01:20

Introduction to the Skeletal System

5.3K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
5.3K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

3.5K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
3.5K
Compact Bone01:27

Compact Bone

11.1K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
11.1K
Spongy Bone01:09

Spongy Bone

4.1K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.

PLoS genetics·2025
Same author

PBX1 and PBX3 transcription factors regulate <i>SHH</i> expression in the Frontonasal Ectodermal Zone through complementary mechanisms.

bioRxiv : the preprint server for biology·2024
Same author

A common <i>cis-</i>regulatory variant impacts normal-range and disease-associated human facial shape through regulation of <i>PKDCC</i> during chondrogenesis.

eLife·2024
Same author

Conserved enhancers control notochord expression of vertebrate Brachyury.

Nature communications·2023
Same author

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.

Developmental biology·2023
Same author

A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.

Nature communications·2023

Related Experiment Video

Updated: Jun 3, 2025

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
10:37

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

2.9K

A long-ignored skeletal tissue filled with oil.

Viviana Hermosilla Aguayo1, Licia Selleri1

  • 1Program in Craniofacial Biology, Department of Orofacial Sciences, Department of Anatomy, Institute for Human Genetics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.

Science (New York, N.Y.)
|January 9, 2025
PubMed
Summary

Lipid vacuoles in mammalian cartilage serve nonmetabolic roles, not just energy storage. This research highlights their structural and functional importance beyond metabolism.

More Related Videos

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

469
Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

665

Related Experiment Videos

Last Updated: Jun 3, 2025

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
10:37

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

2.9K
Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

469
Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research
07:29

Author Spotlight: Advanced Techniques for Characterizing Tissue Mineralization in Bone Regeneration Research

Published on: September 27, 2024

665

Area of Science:

  • Biochemistry
  • Cell Biology
  • Mammalian Physiology

Background:

  • Lipid vacuoles are common cellular components, primarily associated with energy metabolism and storage.
  • Their presence in specialized tissues like cartilage has been less understood, often presumed to be metabolic in nature.

Purpose of the Study:

  • To investigate the functional significance of lipid vacuoles within mammalian cartilage.
  • To determine if lipid vacuoles in cartilage have roles beyond energy metabolism.

Main Methods:

  • Histological analysis of mammalian cartilage tissues.
  • Lipid staining and imaging techniques to identify and characterize lipid vacuoles.
  • Comparative analysis across different mammalian species.

Main Results:

  • Cartilage tissues exhibit a significant abundance of lipid-rich vacuoles.
  • Lipid vacuoles in cartilage show distinct morphological characteristics compared to those in other tissues.
  • Evidence suggests these vacuoles are structurally integrated and not solely for metabolic reserve.

Conclusions:

  • Lipid vacuoles in mammalian cartilage perform crucial nonmetabolic functions.
  • These findings necessitate a re-evaluation of lipid vacuole roles in specialized mammalian tissues.
  • The structural contribution of lipid vacuoles to cartilage integrity is a key area for future research.