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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Multitarget Stool DNA Testing for Colorectal Cancer Screening in Clinical Practice
Linda Jiang1,2, Keming Yang1, Melissa Saul1,3
1Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
The American Journal of Gastroenterology
|January 9, 2025
Summary
Multitarget stool DNA (mt-sDNA) test completion was low at 54.7%, with older patients more likely to complete testing and test positive. Black patients showed lower completion and positive test rates, warranting further study.
Area of Science:
- Gastroenterology
- Oncology
- Clinical Diagnostics
Background:
- Limited data exists on multitarget stool DNA (mt-sDNA) test utilization in routine clinical practice.
- This study examines mt-sDNA usage patterns at the University of Pittsburgh Medical Center.
Purpose of the Study:
- To analyze the utilization of mt-sDNA tests in a clinical setting.
- To identify factors associated with mt-sDNA test completion and positive results.
Main Methods:
- Retrospective analysis of 91,664 mt-sDNA orders from January 2017 to December 2021.
- Data included order capture, stool submission completion, and test results.
- Multivariable models assessed associations between completion/results and patient demographics (age, sex, race).
Main Results:
- Overall mt-sDNA test completion rate was 54.7%.
- Older age (≥60 years) was associated with higher completion and positive test rates.
- Black patients had significantly lower completion rates (38.8%) and lower odds of a positive test compared to White patients.
Conclusions:
- Low completion rates highlight challenges in mt-sDNA test uptake.
- Demographic factors, particularly race and age, influence test completion and positivity.
- Further research is needed to understand mt-sDNA utilization, appropriateness, and outcomes.
