Current trends in the design and fabrication of PRP-based scaffolds for tissue engineering and regenerative medicine

Blood-derived biomaterials with high platelet content have recently emerged as attractive products for tissue engineering and regenerative medicine (TERM). Platelet-derived bioactive molecules have been shown to play a role in wound healing and tissue regeneration processes by promoting collagen synthesis, angiogenesis, cell proliferation, migration, and differentiation. Given their regenerative potential, platelet-rich blood derivatives have become a promising treatment option for use in a variety of conditions. Platelet-Rich Plasma (PRP), one of the platelet-rich blood derivatives, is a platelet concentrate suspended in a small volume of blood plasma obtained from whole blood. Due to its potential clinical benefits, PRP is widely used alone or in combination with various biomaterials/scaffolds in different fields of medicine and has shown promising results in wound healing. The recent growing interest in the development of PRP-based scaffolds also reveals new perspectives on the use of PRP or platelet lysate in TERM. This topical review contains a comprehensive summary of recent trends in the fabrication of PRP-based scaffolds that can deliver growth factors, serve as mechanical support for cells, and have therapeutic or regenerative properties. The article briefly focuses on diverse PRP-based constructs using PRP as a scaffolding material, their current fabrication approaches as well as the challenges encountered and provides a selection of existing strategies and new insights.