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Total cholinesterase in plasma: biological variations and reference limits.

L Lepage, F Schiele, R Gueguen

    Clinical Chemistry
    |April 1, 1985
    PubMed
    Summary

    Plasma cholinesterase activity varies due to genetic and physiological factors. Key influences include genetic status, overweight in males, and hormonal status or oral contraceptives in females, enabling new reference limits.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Genetics

    Background:

    • Plasma cholinesterase activity is a critical biomarker.
    • Understanding biological variation is essential for accurate clinical interpretation.
    • Previous studies have not fully elucidated the multifactorial influences on plasma cholinesterase levels.

    Purpose of the Study:

    • To investigate the key factors contributing to biological variation in total plasma cholinesterase activity.
    • To differentiate the impact of genetic and physiological factors on enzyme activity.
    • To establish reference limits for plasma cholinesterase based on identified influencing factors.

    Main Methods:

    • Studied 3372 healthy individuals aged four and above.
    • Utilized dibucaine number determination to assess enzyme inhibition.
    Keywords:
    Age FactorsBiologyClinical ResearchContraceptionContraceptive Agents, FemaleDemographic FactorsFamily PlanningGeneticsOral ContraceptivesPopulationPopulation CharacteristicsResearch MethodologySex Factors

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  • Employed statistical segmentation to analyze genetic and physiological contributions.

    • Main Results:

    • In males, plasma cholinesterase activity is influenced by genetic status (dibucaine number) and overweight (subscapular skinfold).
    • In females, activity is modulated by hormonal status (puberty, menopause), genetic status (dibucaine number), and oral contraceptive use.
    • Identified distinct contributing factors for males and females.

    Conclusions:

    • Plasma cholinesterase activity is significantly influenced by a combination of genetic and physiological factors.
    • The findings provide a basis for proposing updated reference limits for total plasma cholinesterase.
    • This research enhances the understanding of normal biological variation in plasma cholinesterase levels.