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Statins reduce the recurrence of spontaneous intracerebral hemorrhage: A systematic review and meta-analysis

Chaohua Cui1, Qiulian Yin1, Jiayi Li2

  • 1Life Science and Clinical Medicine Research Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang distract, Baise, Guangxi, China.

Clinical Neurology and Neurosurgery
|January 9, 2025
PubMed

Insights

Statin use was found to reduce the recurrence of intracerebral hemorrhage (ICH). This meta-analysis confirms statins

Area of Science:

  • Neurology
  • Cardiovascular Research
  • Pharmacology

Background:

  • Intracerebral hemorrhage (ICH) recurrence is associated with increased mortality and morbidity.
  • Statins possess neuroprotective properties, suggesting a potential role in preventing ICH recurrence.
  • Existing evidence on statin efficacy for preventing ICH recurrence is inconclusive and debated.

Purpose of the Study:

  • To conduct a meta-analysis of recent studies to determine if statin use reduces the risk of ICH recurrence.
  • To clarify the controversial findings regarding statins and ICH recurrence.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, Embase, and Cochrane Library.
  • Inclusion of original observational cohort studies focusing on patients with intracerebral hemorrhage.
  • Meta-analysis using forest plots and I-squared tests to assess pooled odds ratios and heterogeneity.

Main Results:

  • Seven studies comprising 40,059 patients (6,637 on statins) were included.
  • Overall pooled odds ratio for ICH recurrence was 0.82 (95% CI: 0.68-0.99).
  • Significant reduction in recurrence observed in the 3-year subgroup (OR=0.74) and among Asian patients (OR=0.75).

Conclusions:

  • Statin use is associated with a reduced risk of intracerebral hemorrhage recurrence.
  • The protective effect of statins is significant across all time periods and specifically at 3 years.
  • Statins demonstrated a significant risk reduction for ICH recurrence in the Asian patient subgroup.
Abstract

Keywords:
Intracerebral hemorrhageRecurrenceStage and regionStatinsType

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