Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

36
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
36
Glial Cells01:04

Glial Cells

86.3K
Overview
86.3K
Neuron Structure01:30

Neuron Structure

12.6K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
12.6K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

2.6K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
2.6K
Mitochondria01:37

Mitochondria

10.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
10.5K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

50
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
50

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model.

Nature communications·2026
Same author

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration.

Nature communications·2026
Same author

Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Astrocyte CCN1 stabilizes neural circuits in the adult brain.

Nature·2025
Same author

The antiviral Interferon pathway drives astrocyte aging and motor decline.

bioRxiv : the preprint server for biology·2025
Same author

Astrocyte SEMA3C reduction improves Rett Syndrome phenotypes.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jun 3, 2025

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

91.5K

Astrocytes in aging.

Lara Labarta-Bajo1, Nicola J Allen1

  • 1Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Neuron
|January 9, 2025
PubMed
Summary

Aging significantly impacts the mammalian nervous system, altering brain structure and function. This review explores how aged astrocytes, key central nervous system cells, contribute to these age-related neurological changes and affect brain health span.

Area of Science:

  • Neuroscience
  • Aging Research
  • Cellular Biology

Background:

  • Aging affects the mammalian nervous system, causing brain alterations and cognitive deficits.
  • Astrocytes, crucial glial cells in the central nervous system (CNS), regulate neural circuits but their role in aging is unclear.
  • Transcriptomic changes in astrocytes are observed during aging, particularly in specific brain regions.

Purpose of the Study:

  • To review the features of aged astrocytes.
  • To investigate potential triggers for astrocyte aging.
  • To propose mechanisms by which aged astrocytes impact brain function and health span.

Main Methods:

  • Literature review of studies on astrocyte aging.
  • Analysis of transcriptomic data related to aging astrocytes.
Keywords:
CNSagingastrocytebraingliainflammation

More Related Videos

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

9.8K
A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

9.3K

Related Experiment Videos

Last Updated: Jun 3, 2025

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

91.5K
Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
15:08

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions

Published on: October 21, 2017

9.8K
A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

9.3K
  • Synthesis of current knowledge on astrocyte function in aging.

    • Main Results:

    • Aging induces significant transcriptomic alterations in astrocytes.
    • Specific brain regions like the cerebellum and hypothalamus show pronounced astrocyte changes.
    • The functional consequences of these aged astrocyte states remain largely unknown.

    Conclusions:

    • Aged astrocytes exhibit distinct features and are influenced by specific triggers.
    • Understanding aged astrocytes is critical for addressing age-related neurological decline.
    • Further research is needed to elucidate how aged astrocytes impact brain function and health span.