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Updated: Jun 3, 2025
A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
Published on: July 2, 2014
Comparable Performance Between Automatic and Manual Laryngeal and Hypopharyngeal Gross Tumor Volume Delineations
Koen M Kuijer1, Hilde J G Smits2, Patricia A H Doornaert2
1Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands; Technical Medicine, University of Twente, Enschede, The Netherlands.
Purpose:
Deep learning is a promising approach to increase reproducibility and time-efficiency of gross tumor volume (GTV) delineation in head and neck cancer, but model evaluation primarily relies on manual GTV delineations as reference annotation, which are subjective and tend to overestimate tumor volume. This study aimed to validate a deep learning model for laryngeal and hypopharyngeal GTV segmentation with pathology and to compare its performance with clinicians' manual delineations.
Methods And Materials:
A retrospective data set of 193 patients with laryngeal and hypopharyngeal cancer was used to train a deep learning model with clinical GTV delineations as reference. For validation, a data set comprising 18 patients who underwent imaging before total laryngectomy was used, with histopathology-based (n = 16) tumor delineations as ground truth. The performance of the automatic segmentations was compared with that of clinicians' manual delineations, both quantitatively and qualitatively.
Results:
Median sensitivity (0.90 and 0.91) and largest required clinical target volume margin (6.4 and 6.6 mm) were comparable between automatic and manual GTV delineations. The positive predictive value yielded the only significant difference between automatic and manual GTV delineations, with medians of 0.52 and 0.61, respectively (P = .03). Clinical target volumes derived from automatic and manual GTVs exhibited similar sizes (median of 44.5 and 40.1 mL) and achieved a sensitivity of 1.00 in 13/16 and 14/16 tumors, respectively. Automatic segmentations were considered clinically acceptable in 67% of cases, compared with 63% of manual delineations.
Conclusions:
The proposed deep learning model for laryngeal and hypopharyngeal GTV segmentation achieved comparable results with clinicians' manual delineations, showing the potential for more consistency and efficiency in the radiation therapy workflow.
