Prevalence and Risk Factors of Stroke in Patients with Nonvalvular Atrial Fibrillation: A Case-Control Study

To analyze the prevalence and influencing factors of stroke in patients with nonvalvular atrial fibrillation (SIPWNVAF), and to provide a reference basis for the prevention and control of stroke.

Data were obtained from the China National Stroke Screening Survey. From January 2016 to December 2023, a total of 15,471 permanent residents aged ≥40 years in Yinchuan were screened. Patients with nonvalvular atrial fibrillation who had their first stroke were selected as the stroke group (86 patients), and patients with nonvalvular atrial fibrillation who had never had a stroke as the control group (477 patients).

In 563 residents, the crude prevalence of SIPWNVAF was 15.28%, and the standardized prevalence was 9.33%. The multivariable logistic regression analysis revealed that age (odds ratio [OR]: 1.42; 95% confidence interval [CI]: 1.17-1.71), smoking (OR: 2.10; 95% CI: 1.46-3.01), drinking (OR: 2.00; 95% CI: 1.28-3.13), lack of exercise (OR: 2.18; 95% CI: 1.18-4.03), family history of stroke (OR: 4.39; 95% CI: 1.82-10.57), hypertension (OR: 1.94; 95% CI: 1.03-3.63), diabetes (OR: 3.10; 95% CI: 1.37-7.05), dyslipidemia (OR: 2.15; 95% CI: 1.16-3.99), homocysteine ≥15 μmol/L (OR: 2.13; 95% CI: 1.14-3.97), and carotid atherosclerosis (OR: 2.86; 95% CI: 1.53-5.37) were independent risk factors, but educational level (OR: 0.31; 95% CI: 0.17-0.58) was a protective factor for SIPWNVAF.

The stroke group is significantly more burdened by other independent common risk factors for stroke.