Reduction of postoperative ileus in gastrointestinal surgery: systematic review and meta-analysis

Postoperative ileus is a surgical complication that affects intestinal motility. There are measures to reduce this problem, but not all have conclusive evidence. This study aimed to determine which measures, such as coffee, chewing gum (CG), electroacupuncture (EA), daikenchuto (DKT), and prokinetic agents, are most effective in reducing postoperative ileus in patients undergoing gastrointestinal surgeries.

A systematic search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines on Google Scholar, PubMed, ScienceDirect, and Web of Science. The following measures were studied to define postoperative ileus: time to passage of the first flatus and time to passage of the first stool. The mean differences were determined by subgroup analyses.

Of 176 studies, 37 were selected for the systematic review, which involved 4647 patients. The reduction in time to passage of the first flatus was -18.33 h (95% CI, -26.46 to -10.20; P <.01) for EA, -5.83 h (95% CI, -9.40 to -2.26; P <.01) for DKT, -14.87 h (95% CI, -26.84 to -2.90; P =.01) for CG, and -1.90 h (95% CI, -8.28 to 4.48; P =.56) for coffee. The reduction in time to passage of the first stool was -32.27 h (95% CI, -39.28 to -25.26; P <.01) for prokinetic agents, -23.05 h (95% CI, -29.31 to -16.78; P <.01) for CG, -12.89 h (95% CI, -17.78 to -8.01; P <.01) for coffee, -19.76 h (95% CI, -32.79 to -6.72; P <.01) for EA, and -0.70 h (95% CI, -25.51 to 26.92; P =.96) for DKT.

The use of CG, EA, and prokinetic agents decreased the time to passage of the first flatus and time to passage of the first stool and indirectly reduced postoperative ileus.