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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

Integrative bioinformatics and immunohistochemical analysis unravel the prognostic significance and immunological

Xin Yu¹, Bei Li², Wenge Li³

¹Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, 238 Ziyang Road, Wuhan, 430060, Hubei, People's Republic of China.

Scientific Reports

|January 9, 2025

Summary

High LIMCH1 protein expression in breast cancer is linked to poor prognosis and an immunosuppressive tumor microenvironment. This finding highlights LIMCH1 as a potential prognostic indicator and therapeutic target for breast cancer patients.

Keywords:

Bioinformatics Breast cancer LIMCH1 Therapeutic target Tumour immunity

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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

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Published on: September 15, 2023

Area of Science:

Oncology
Molecular Biology
Immunology

Background:

High breast cancer mortality necessitates improved prognostic tools.
LIM and calponin homology domain 1 (LIMCH1) protein has dual roles in cancer and warrants investigation.
Understanding LIMCH1's function is crucial for developing new breast cancer therapies.

Purpose of the Study:

To investigate the expression patterns of LIMCH1 in breast cancer.
To analyze the association of LIMCH1 with clinicopathological features, prognosis, and the tumor immune microenvironment (TIME).
To explore the molecular mechanisms underlying LIMCH1's role in breast cancer pathogenesis.

Main Methods:

Integrative analysis combining The Cancer Genome Atlas (TCGA) bioinformatics data and clinical immunohistochemistry (IHC) cohort data.
Exploration of functional annotations and single-cell RNA sequencing (scRNA-seq) data.
Development of a nomogram for predicting overall survival rates.

Main Results:

High LIMCH1 expression correlates with unfavorable clinical outcomes and serves as an independent prognostic indicator in breast cancer.
LIMCH1 is implicated in carcinogenesis and metabolic reprogramming pathways, suggesting its role in tumor progression.
LIMCH1 expression is associated with an immunosuppressive TIME, characterized by increased M2 macrophages and decreased CD8+ T cells and NK cells.

Conclusions:

LIMCH1 plays diverse roles in breast cancer pathogenesis.
LIMCH1 holds potential as a prognostic indicator for breast cancer patients.
LIMCH1 represents a potential therapeutic target for breast cancer intervention.