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Standardising lipid testing and reporting in the United Kingdom; a joint statement by HEART UK and The Association

Julia S Kenkre1,2, Tina Mazaheri1,2, R Dermot G Neely3,4

  • 1Department of Clinical Biochemistry, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.

Annals of Clinical Biochemistry
|January 10, 2025
PubMed

Insights

New UK guidelines offer evidence-based lipid testing recommendations for laboratories and clinicians to assess cardiovascular risk. This aims to improve management of atherosclerotic cardiovascular disease, a leading cause of premature death.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Public Health

Background:

  • Atherosclerotic cardiovascular disease is a leading cause of premature mortality in the UK.
  • Lipid testing is crucial for cardiovascular risk assessment and clinical decision-making.
  • Existing national guidelines for lipid testing and reporting in the UK are lacking.

Purpose of the Study:

  • To establish consensus-based, evidence-driven guidelines for lipid testing and reporting in the UK.
  • To provide recommendations for standard and enhanced lipid profiles.
  • To guide laboratories and clinicians in interpreting and reporting lipid test results.

Main Methods:

  • A multidisciplinary group of UK experts reviewed published evidence.
  • Consensus was reached on key aspects of lipid testing and reporting.
  • Guidance was developed for standard and enhanced lipid profiles, including specific analytes and calculations.

Main Results:

  • Recommendations cover the composition of standard and enhanced lipid profiles.
  • Specific guidance is provided for including apolipoprotein B and lipoprotein (a).
  • The Sampson-NIH calculation for LDL-c estimation and criteria for flagging abnormal results are recommended.

Conclusions:

  • The consensus guidance provides a framework for consistent lipid testing and reporting across the UK.
  • Implementation of these guidelines can enhance cardiovascular risk assessment and patient management.
  • The guidance is endorsed by HEART UK and The Association for Laboratory Medicine.

Keywords:
Lipidscardiovascular diseaseguidelineslaboratory

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